This regional supplement to Business and Human Rights – A Guidebook for National Human Rights Institutions introduces African regional frameworks and standards relevant to business and human rights, such as key human rights conventions and governance institutions of the African Union, the Action Plan for Implementing the Africa Mining Vision, and regional financial institutions. The chapter also outlines business and human rights activities of the Network of African National Human Rights Institutions (NANHRI) and NANHRI’s Yaoundé Action Plan on Business and Human Rights. The chapter concludes with some NHRI practice examples in the area of business and human rights.